Antimicrobial and antiparasitic activities of three algae from the northwest coast of Algeria

<p>The objective of this study was to investigate the biological activities of Algerian algae, <i>Sargassum vulgare, Cladostephus hirsutus</i> and <i>Rissoella verruculosa</i>. Antimicrobial activity of the crude extracts and their fractions was assessed using the disc diffusion assay, the minimum inhibitory concentration and the minimum bactericidal concentration. Antiparasitic activity was studied <i>in vitro</i> against the blood stream forms of <i>Trypanosoma brucei brucei</i> and the intraerythrocytic stages of <i>Plasmodium falciparum</i>. Ethyl acetate (EA) fractions of the three tested algae showed more potent antimicrobial activity against <i>S</i>. <i>aureus</i> (7–14.5 mm) and <i>B</i>. <i>cereus</i> (7–10.75 mm), MIC values ranged from 0.9375 to 7.5 mg mL<sup>−1</sup> and MBC values > 15 mg mL<sup>−1</sup>. Concerning the antiparasitic activity, EA factions of <i>S. vulgare</i> (IC<sub>50</sub> = 9.3 μg mL<sup>−1</sup>) and <i>R. verruculosa</i> (IC<sub>50</sub> = 11.0 μg mL<sup>−1</sup>) were found to be more effective against <i>T. brucei brucei</i>, whereas the three EA fractions were little active against <i>P. falciparum</i>.</p>