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Antigenic residues according to Epitome
figure
posted on 2011-12-30, 15:37 authored by Avner Schlessinger, Yanay Ofran, Guy Yachdav, Burkhard RostCopyright information:
Taken from "Epitome: database of structure-inferred antigenic epitopes"
Nucleic Acids Research 2005;34(Database issue):D777-D780.
Published online 28 Dec 2005
PMCID:PMC1347416.
© The Author 2006. Published by Oxford University Press. All rights reserved
Complex structure of quail lysozyme (in blue) and the light chain of an antibody (in green), as taken from PDB ID 1bql (). The residues that are defined to be in CDR 1 of the light chain according to Kabat definition () are colored in black. Residues in red are all the residues that are involved in the interaction according to Epitome. Note that not all of the residues on the antibody surface that are located on ‘Kabat’ CDR are involved in the antigenic reaction. Additionally, although 1bql antibody chains did not participate in the multiple structure alignment, i.e. the information about the location of the CDR was transferred from a homologous structure, the interaction was correctly identified.