Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel – A comparative study

<p>The present study was conducted to identify the chemical constituents and evaluate the anti-inflammatory activity of crude ethanolic extracts of spine, skin and rind of jack fruit (<i>Artocarpus heterophyllus</i>) peel. Polyphenol and flavonoid contents were assessed using Folin’s Ciocalteu reagent and aluminium chloride methods which revealed 316, 355 and 382 mg tannic acid equivalent/g of polyphenol and 96.7, 131.6 and 164.6 mg quercetin equivalent/g of flavonoid in spine, skin and rind, respectively. Anti-inflammatory activity of all three extracts was comparable to diclofenac <i>in vitro</i> and <i>in vivo</i> studies<i>.</i> Skin exhibited maximum anti-inflammatory activity, rind had preferential inhibition on Cyclooxygenase-2 and spine and skin inhibited both Cyclooxygenase-1 and 2 <i>in vitro</i>.</p>