np9b00283_si_001.pdf (1.55 MB)
Anti-inflammatory and α‑Glucosidase Inhibitory Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes of Amomum villosum
journal contribution
posted on 2019-11-08, 19:47 authored by Hong Yin, Wen-Jia Dan, Bo-Yi Fan, Chao Guo, Kui Wu, Ding Li, Kui-Feng Xian, Gennaro Pescitelli, Jin-Ming GaoA new tetranorditerpenoid (1), two new labdane diterpenoids
(2, 3), and nine known analogues (4–12) were isolated from the rhizomes
of Amomum villosum var. xanthioides. Compound 1 is an unprecedented rearranged tetranorlabdane
diterpenoid, featuring a 6/6/5 fused tricarbocyclic skeleton with
an α,β-unsaturated cyclopentenone unit, while 2 is a structurally rare labdane diterpenoid carrying a five-membered
cyclic anhydride moiety. Their structures and absolute configurations
were established on the basis of spectroscopic data and the experimental
and calculated ECD data. Compound 4 showed inhibitory
activity against nitric oxide production, with an IC50 value
of 2.4 μM, and also inhibited α-glucosidase activity (IC50 = 10.0 μM).
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labdane diterpenoidECD dataIC 50α- glucosidase activityAmomum villosumnitric oxide productionAmomum villosum varspectroscopic dataNorlabdane Diterpenoids10.0 μ Mfive-membered cyclic anhydride moietytricarbocyclic skeletonIC 50 valuetetranorlabdane diterpenoid2.4 μ Mlabdane diterpenoidsCompound 1Compound 4cyclopentenone unit
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