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Alginate Nanofibrous Mats with Adjustable Degradation Rate for Regenerative Medicine
journal contribution
posted on 2015-03-09, 00:00 authored by Hadi Hajiali, José
A. Heredia-Guerrero, Ioannis Liakos, Athanassia Athanassiou, Elisa MeleThe
broad utilization of electrospun scaffolds of sodium alginate
in tissue engineering is strongly limited by their high solubility
in aqueous environments and by the difficulty to adjust their degradation
dynamics. Here, an alternative strategy to enhance the stability and
to control the degradability of alginate nanofibers is described by
treating them with trifluoroacetic acid for specific time intervals.
It is demonstrated that, by increasing the duration of the acid treatment
procedure, a lower degradation rate of the resulting fibers in buffer
solutions can be achieved. Furthermore, the produced mats are free
from cytotoxic compounds and are highly biocompatible. The properties
conferred to the alginate nanofibrous mats by the proposed method
are extremely attractive in the production of innovative biomedical
devices.
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Regenerative MedicineThetissue engineeringbuffer solutionsacid treatment proceduresodium alginatetrifluoroacetic acidalginate nanofibersAdjustable Degradation Rateelectrospun scaffoldsdegradation ratealginate nanofibrous matsdegradation dynamicscytotoxic compoundsAlginate Nanofibrous Matstime intervalsalternative strategy
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