pone.0202150.g003.tif (494.15 kB)
Adipose tissue function is not affected by macrophage CD40 deficiency.
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posted on 2018-08-10, 17:39 authored by Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens(A) Adipocyte size after 13 weeks of dietary intervention. (B) Plasma triglycerides (TG). (C) Plasma total cholesterol levels. (D) plasma adiponectin levels are increased in lean macrophage CD40 deficient mice but are not different in obese mice. (E) Plasma leptin levels. (F) mRNA expression of adiponectin, leptin, PPARγ and insulin receptor (IR) in EpAT, (n = 6–9 mice/group). Data is presented as mean ± SEM. *p<0.05, as determined by non-parametric Mann Whitney test.
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adipose tissue leukocyte infiltrationWT40LMacrophage CD 40SFDadipose tissue inflammation40-CDameliorates adipose tissue inflammationinsulin resistanceHFDCD 40 flfl LysM creincreases insulin sensitivitymacrophage CD 40adipose tissue weightDIOplasma adiponectin levelstriglyceride levelsmacrophage CD 40. CD 40 flfl LysM cre miceadipose tissue cytokine levels
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