Additional file 7: Figure S6. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Inhibition of RT-QuIC reaction by Doxycycline. RT-QuIC assay performed in the presence of sCJD brain homogenates (n = 3) as seeding material, previously treated with recombinant Calpain in the presence (+DOX) of absence (−DOX) of Doxycycline (DOX). Relative Fluorescence Units (RFU) are shown. (PPTX 47 kb)