Additional file 7: Figure S6. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Llorens, Franc; Thüne, Katrin; Sikorska, Beata; Schmitz, Matthias; Tahir, Waqas; Fernández-Borges, Natalia; Cramm, Maria; Gotzmann, Nadine; Carmona, Margarita; Streichenberger, Nathalie; Michel, Uwe; Zafar, Saima; Schuetz, Anna-Lena; Rajput, Ashish; Andréoletti, Olivier; Bonn, Stefan; Fischer, Andre; Liberski, Pawel; Torres, Juan; Ferrer, Isidre; Zerr, Inga

doi:10.6084/m9.figshare.c.3758096_D7.v1

40478_2017_431_MOESM7_ESM.pptx (47.61 kB)

Additional file 7: Figure S6. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

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posted on 2017-04-27, 05:00 authored by Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn, Andre Fischer, Pawel Liberski, Juan Torres, Isidre Ferrer, Inga Zerr

Inhibition of RT-QuIC reaction by Doxycycline. RT-QuIC assay performed in the presence of sCJD brain homogenates (n = 3) as seeding material, previously treated with recombinant Calpain in the presence (+DOX) of absence (−DOX) of Doxycycline (DOX). Relative Fluorescence Units (RFU) are shown. (PPTX 47 kb)

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Robert Koch Institute (Germany)

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Creutzfeldt-Jakob disease Prion protein Calpain Cathepsin Calcium Ca2+

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Additional file 7: Figure S6. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

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Robert Koch Institute (Germany)

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