Additional file 6: Figure S3. of Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats

Neonatal inflammatory pain didn’t cause spatial and olfactory memory impairments in juvenile rats. A-D. Juvenile male and female rats in the control or formalin groups were evaluated for spatial memory in the Morris water maze test. A. Latency to escape to the platform during the 6 day training session. There were no significant differences between the groups. n = 13 per group. B. Swim distance to reach the platform during training. There were not significant differences between groups. n = 13 per group. C and D. The place preference test was conducted at day 7 when the platform was removed after the last training day. All animals spent more time in the target quadrant (platform quadrant) (C), but there were no statistical differences between groups (D). n = 13 per group. E and F. Juvenile male and female rats in control or formalin groups were evaluated for olfactory memory in the social transmission of food preference test. There were no significant differences in the amount of total food consumed and the percentage of preference for cued food (almond) between groups. n = 8-15 per group. (TIF 1085 kb)