Additional file 5: Figure S4. of miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway

miR-663a is upregulated in Caco2 cells treated with LL-37 and FF/CAP18 the same as in HCT116 cells. (A) Viability of Caco2 cells after treatment with LL-37, FF/CAP18, or Sc/FF for 48 h at the concentration of 100–1.5625 μg/mL. Each data is presented as mean ± SD of triplicate experiments. (* p < 0.05; ** p < 0.001). Caco2 cells were purchased from RIKEN Bioresource Center (RBRC-RCB0988) and maintained in a same condition as HCT116 cells. (B) Relative expression of miR-663a in Caco2 cells treated with LL-37 (40, 80 μg/mL) and FF/CAP18 (40 μg/mL). Each data is shown as mean ± SD of triplicate experiments. (* p < 0.05; ** p < 0.001). (JPG 469 kb)