Additional file 3: Figure S3. of Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal stem cells in a rabbit model

Histopathological analysis of the influence of MSC in a glucocorticoid-associated rabbit osteonecrosis model. Osteonecrosis was considered to be present when necrosis of medullary haematopoietic cells and fat cells (black arrow), and/or osteocyte empty lacunae and condensed nuclei were evident. In 7 of 8 rabbits no bone marrow necrosis or osteonecrosis was evident (a, b, c, d, e, f, g), while in only a single specimen (12.5%) were necrotic or degenerated cells found in a part of the bone marrow (h). Magnification: ×100. (TIFF 650 kb)