Additional file 3: Figure S3. of Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

Diffuse staining pattern of Cathepsin D (Cat D) (ab6313, Abcam) in tauopathies a-h Merged pictures show immunofluorescence staining of Cat D (green) and DAPI (nuclear marker, blue). a-c Diffuse immunoreactivity for Cat D in FAD, CBD and PSP patients (arrows) and distinct vesicle-like structures (asterisks). d and h Control samples show Cat D-positive vesicular-like structure (asterisks) and not diffuse staining. e-h High magnification of the boxed areas in a-d. Scale bars: 50 μm (20 μm high magnification). (TIF 25515 kb)