Additional file 3: Figure S2. of Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas

Tumor latency of the mouse models and histological analyses of TAN skin from un-treated and acute-UVB treated mice. (a) Kaplan-meier curve showing tumor latency in the untreated and UVB treated mice. Reduced tumor latency seen in UVB treated mutant mice compared to UVB untreated mutants. Ticks indicate when a mouse in that group was censored (removed from the study). (b, c) H&E staining of TAN skin of non-UVB treated skin and TAN skin from acute-UVB treated mice. In all groups, TAN skin has similar morphology in both the non-UVB treated skin and single neonatal UVB treated skin, except for increased epidermal thickening; and deeper dermal pigmentation seen in the RXRαep−/− mice. E = Epidermis, D = Dermis, scale bar =100 μm. (TIFF 2257 kb)