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Additional file 3: Figure S2. of Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas
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posted on 2017-11-09, 05:00 authored by Sharmeen Chagani, Rong Wang, Evan Carpenter, Christiane Löhr, Gitali Ganguli-Indra, Arup IndraTumor latency of the mouse models and histological analyses of TAN skin from un-treated and acute-UVB treated mice. (a) Kaplan-meier curve showing tumor latency in the untreated and UVB treated mice. Reduced tumor latency seen in UVB treated mutant mice compared to UVB untreated mutants. Ticks indicate when a mouse in that group was censored (removed from the study). (b, c) H&E staining of TAN skin of non-UVB treated skin and TAN skin from acute-UVB treated mice. In all groups, TAN skin has similar morphology in both the non-UVB treated skin and single neonatal UVB treated skin, except for increased epidermal thickening; and deeper dermal pigmentation seen in the RXRαep−/− mice. E = Epidermis, D = Dermis, scale bar =100 μm. (TIFF 2257 kb)