Additional file 3: Figure S2. of A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma

Inhibition of MYC by MYC-MAD transfection in RR cells significantly decreased the SRR2 luciferase activity. The SRR2 luciferase activity in RR cells derived from SupM2 and Karpas 299 with EV or MYC-MAD transfection at 48 h. The western blots results showed the protein levels of p-MYCS62 and MYC in RR cells from the two cell lines after MYC-MAD transfection at 48 h; cells with EV transfection were included as a control. (PDF 148 kb)