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Additional file 2: of Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy

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posted on 17.01.2017 by Nora Huang, Melanie Kny, Fabian Riediger, Katharina Busch, Sibylle Schmidt, Friedrich Luft, Hortense Slevogt, Jens Fielitz
Polymicrobial sepsis increases Nlrp3, Il1b, and Il6 expression in the muscle. Twelve-week-old male C57B16/J mice were subjected to cecal ligation and puncture (CLP) or sham surgery (sham), as indicated. (A) qRT-PCR analysis of Nlrp3, IL-1β, and Il6 expression in gastrocnemius/plantaris (GP) and (B) tibialis anterior (TA) muscles of sham (n = 5) and CLP (n = 5) mice 4 days after surgery. mRNA expression was normalized to Gapdh. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. (EPS 1161 kb)

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