Additional file 2: Figure S1. of Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort

Mapping of the detected mutations to the protein sequences within respective domains in the ten most frequently mutated and relevant genes is this study. Mutations in CREBBP and EP300 always occurred within the HAT domain responsible for acetylation. In SOCS1, mutations were distributed evenly along the protein sequence. Y-axis represents the number of mutations detected at a particular amino acid position. Green–missense mutation; black–frameshift insertion/deletion; purple–nonsense mutation. (PDF 442 kb)