Additional file 1: of Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology

Supplementary figures S1-S7 and supplementary text. Figure S1. First axis of the lower-specific and upper-specific PCAs orders samples with time. Figure S2. Gene ontology analysis of the genes robustly assigned to one of the ten clusters obtained for lower and upper molar. Figure S3. Mesenchyme proportion estimated using deconvolutions with markers based on microarray data. Figure S4. Mesenchyme proportion are always larger in upper molar as measured from 3D reconstructions of dissected tooth germs. Figure S5. Models of cusp patterning and expansion in the lower and upper molars. Figure S6. Heterochrony signals are visible in the transcriptomes of each tissue compartment. Figure S7. In a limb development dataset, PCA1 coordinates correlate with proportions of chondrocytes estimated by deconvolution (see supplementary text). Supplementary text. Time signal and heterochrony in limb development can be interpreted alongside with estimation of the proportion of differentiated cell types. (PDF 3938 kb)