Additional file 1 of Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype

Hierarchical clustering and CIMP status of samples in each tissue. Each sample is represented by the methylation levels of the 5 % of the probes that vary most in the tissue considered. Heatmaps range from hypomethylated (blue) to hypermethylated (yellow). The column colorbar represents the resulting assignment of each sample as CIMP positive (yellow) or CIMP negative (blue). Panel A. bladder; panel B. breast; panel C. colon; panel D. lung; panel E. stomach. (PDF 13722 kb)