Additional file 1: of A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

Figures S1 to S6. Figure S1: The expression of proteins in GC cells and the sequences of ectopic MACC1 and shRNA. Figure S2: The combination of trastuzumab and glycolysis inhibitors synergisticly inhibit glycolysis in HER2 positive GC cells. Figure S3: The combination of trastuzumab and glycolysis inhibitors synergisticly inhibit glycolysis in HER2 positive GC cells. Figure S4: MACC1 enhanced the Warburg effect in vivo. Figure S5: Combination of trastuzumab and oxamate effectively inhibited the Warburg effect in vivo. Figure S6: The apoptosis of indicated cells after treated with Ttzm. (ZIP 38363 kb)