Additional file 1: Figure S1. of Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Periodontal infection induces active inflammation in polymicrobial infected + CII immunized mice. Polymicrobial-infected + CII immunized mice, left metatarsal tissue H&E staining showing active inflammation with infiltration of neutrophils and macrophages. A × 1 magnification, B × 2 magnification, C × 10 magnification (top panel). I, II, III, IV, and V are digits. CII-immunized mice metatarsal tissue H&E staining showing minimal inflammation (A × 1, B × 2, and C × 10 magnification (bottom panel)). N = 6 in each group. (TIF 2050 kb)