Additional file 1: Figure S1. of Complement activation at the motor end-plates in amyotrophic lateral sclerosis

Representative confocal immunofluorescence for synaptophysin (SYN-Cy3) detecting the motor nerve terminal (A, B) or S100b (Cy3) detecting the terminal Schwann cells (C, D) double stained with anti-C1q (FITC) in control (A, C) and ALS (B, D) intercostal muscle shows C1q co-localizing with both synaptophysin and S100b (white arrow in B and D, respectively) but no C1q deposition in controls. (TIF 1461 kb)