Additional file 1: Figure S1. of Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers

Bidirectional transcription (as measured by CAGE) initiation around DHSs in Gm12878 cells. Figure S2. Bidirectional transcription (as measured by CAGE) initiation around DHSs in K562 cells. Figure S3. Bidirectional transcription (as measured by CAGE) initiation around DHSs in HepG2 cells. Figure S4. Bidirectional transcription (as measured by CAGE) initiation around DHSs in Huvec cells. Figure S5. Bidirectional transcription initiation around DHSs in K562 cells. Figure S6. Bidirectional transcription (as measured by GRO-seq) initiation around DHSs in Gm12878 cells. Figure S7. Bidirectional transcription (as measured by GRO-seq) initiation around DHSs in K562 cells. Figure S8. Bidirectional transcription (as measured by PRO-seq) initiation around DHSs in K562 cells. Figure S9. Bidirectional transcription initiation (as measured by GRO-cap) across DHSs which do not overlap annotated promoters in two cell lines across various chromatin state annotations. Figure S10. Bidirectional transcription (as measured by CAGE) across DHSs which do not overlap annotated promoters in four cell lines across various chromatin state annotations. Figure S11. Productive transcription as measured by the elongation rates of transcripts initiating from various genome annotations and chromatin states. Figure S12. Correlations between chromatin state loci and bidirectionally transcribed-defined enhancers with the nearest annotated gene promoter. Figure S13. Correlations between chromatin state loci and bidirectionally transcribed-defined enhancers with annotated gene promoters within 500 kb. Figure S14. Correlations between chromatin state loci and bidirectionally transcribed-defined enhancers with annotated gene promoters within the same physical domain. Figure S15. Correlations between chromatin state loci and bidirectionally transcribed-defined enhancers with physically interacting annotated gene promoters. (PDF 1830 kb)