Additional file 11: Figure S6. of Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells

a Plot of Z-score versus percentage GC content for transcription factor binding sites detected in promoter regions of zebrafish genes belonging to cluster 4 (n = 178 genes). The red dashed line defines background level (Z- score > mean + 2 standard deviations). b Detection of Hsf1 binding site in −1 kb relative to transcription start site of human orthologous genes from each cluster obtained by fuzzy mean clustering. The number of human orthologs found is indicated for each cluster. Asterisks indicate significant enrichment of Hsf1 binding sites. c Example of genome browser views of human HSF1 ChIP-Seq data for four genes belonging to cluster 4. Gene name, structure and directionality are indicated for each gene, as well as HSF1 (pink) and H3K27Ac (black) chromatin immunoprecipitation tracks. Hsf1 binding sites are indicated by red arrows. (PDF 546 kb)