Activating AcH3 and repressive H3K27me3 histone modifications on the KSHV genome in classic KS tissues.

The general maps of AcH3 and H3K27 histone modifications on KSHV genome are illustrated. Sequence reads for AcH3, H3K27me3 and Input samples were aligned to the KSHV genome (HQ404500+35TR) and visualized in IGV software. Values shown on the y axis represent the relative enrichment of ChIP-Seq signals and has been normalized according to the calculated normalization factors. The epigenetic maps illustrated in the figure contain information from two cases of classic KS tissues. 1#: the first case. 2#: the second case. The signals of AcH3 and H3K27 histone modifications were overlaid with the signals of Input (baseline) respectively. Red: AcH3 or H3K27. Blue: Input. *: the promoter region of vIRF3 gene. **: the latent locus.