ppat.1006575.g001.tif (268.35 kB)
A synthetic bryostatin analog exhibits pan-PKC binding selectivity similar to bryostatin 1.
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posted on 2017-09-21, 09:09 authored by Matthew D. Marsden, Brian A. Loy, Xiaomeng Wu, Christina M. Ramirez, Adam J. Schrier, Danielle Murray, Akira Shimizu, Steven M. Ryckbosch, Katherine E. Near, Tae-Wook Chun, Paul A. Wender, Jerome A. ZackA) Structure of bryostatin 1. B) Structure of bryostatin analog SUW133. C) & D) Affinities of bryostatin 1 and SUW133 in binding to conventional and novel PKC isoforms.
