lsyc_a_1365907_sm8020.pdf (1.47 MB)
Short eight-steps total synthesis of racemic asteriscunolide C
Version 2 2017-10-16, 13:40
Version 1 2017-08-21, 18:37
journal contribution
posted on 2017-10-16, 13:40 authored by Rodney A. Fernandes, Vijay P. Chavan, Arpita PanjaA concise total synthesis of racemic asteriscunolide C in eight steps has been described starting from neopentane diol involving an efficient Yamaguchi esterification using an aldehyde-acid, intramolecular Horner–Wittig–Emmons olefination, and a late stage ring-closing metathesis to construct the strained 11-membered ring with one Z- and two E-double bonds.