A pharmacophore of ebola active compounds

2014-10-02T14:14:20Z (GMT) by Sean Ekins
<p>Two 2013 papers yielded 4 FDA compounds active vs Ebola virus in vitro and in vivo. These were used to build a pharmacophore and virtually screen libraries.</p> <p>Estradiol does not have the basic nitrogen common to the 4 active compounds but Madrid showed it was active in vitro but not against viral replication.</p>