A pan-European phylodynamic study of HIV-1 transmission networks

2012-09-05T08:57:21Z (GMT) by Prabhav Kalaghatgi
<p>THE ECDC <a href="http://www.ecdc.europa.eu/en/publications/Publications/Forms/ECDC_DispForm.aspx?ID=785">reports</a> around 100,000 new infections in Europe and Central Asia in 2010 with large variance in incidence and dominant mode of transmission across different countries. This study reconstructed HIV transmission networks and investigated patterns of epidemic growth and spread from a Europe wide dataset of 30,000 patients.</p> <p>We find that the reconstructed transmission graph, where vertices represent patients and edges, a transmission between them, has has assortativity coeffienct (~ 0.6) which suggests endogenous growth of the HIV epidemic in Europe. Temporal evolution of the epidemic, which is estimated from reconstructed phylogenetic trees, indicates episodic growth which probably reflects the community structure of the contact network.</p> <p>This poster will be presented at ECCB 2012. </p> <p> </p>