A new sesquiterpene from the gorgonian coral Menella sp.

Peng, Qi; Liu, Fen; Sun, Huan; Liao, Xiao-Jian; Feng, Mei-Ran; Liu, Ting-Ting; Xu, Zheng-Xiong; Zhang, Jun; Xu, Shi-Hai

doi:10.6084/m9.figshare.3153691.v1

gnpl_a_1166496_sm1809.pdf (581.41 kB)

A new sesquiterpene from the gorgonian coral Menella sp.

journal contribution

posted on 2016-04-04, 19:59 authored by Qi Peng, Fen Liu, Huan Sun, Xiao-Jian Liao, Mei-Ran Feng, Ting-Ting Liu, Zheng-Xiong Xu, Jun Zhang, Shi-Hai Xu

A new sesquiterpene named menecubebane B (1) and a known analogue (2) were isolated from the gorgonian coral Menella sp. Their structures were elucidated by the extensive analyses of spectroscopic data and by the comparison with related literature. Cytotoxic effect against both Eca9706 and HeLa cell lines was evaluated, revealing 1 exhibited moderate cytotoxicity against the two cell lines involved with IC₅₀ values being 20.8 and 30.6 μM, respectively.