A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Wang, Jun-Feng; Xu, Fu-Quan; Wang, Zhen; Lu, Xin; Wan, Jun-Ting; Yang, Bin; Zhou, Xue-Feng; Zhang, Tian-Yu; Tu, Zheng-Chao; Liu, Yonghong

doi:10.6084/m9.figshare.1000667.v2

gnpl_a_905935_sm5576.doc (3.65 MB)

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Version 2 2014-06-30, 08:25

Version 1 2014-06-30, 08:25

journal contribution

posted on 2014-06-30, 08:25 authored by Jun-Feng Wang, Fu-Quan Xu, Zhen Wang, Xin Lu, Jun-Ting Wan, Bin Yang, Xue-Feng Zhou, Tian-Yu Zhang, Zheng-Chao Tu, Yonghong Liu

One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3–7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1–7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC₅₀ values of 12.2 μM.