A new amino amidine derivative from the wood-decaying fungus <i>Xylaria</i> cf. <i>cubensis</i> SWUF08-86

<p>The secondary metabolites of <i>Xylaria</i> cf. <i>cubensis</i> SWUF08-86 fungus were investigated, and the chromatographic separation of the crude extracts yielded seventeen compounds. The structure elucidation by spectroscopic analysis including 1D and 2D NMR and the comparison of these data with literature, along with HREIMS spectrometry, revealed one new amino amidine derivative (<b>1</b>), together with five known simple cyclic dipeptide analogs, diketopiperazines (<b>2</b>–<b>6</b>) and eleven other known compounds, including one <i>hemi</i>-cycline (<b>10</b>), three aromatic derivatives (<b>11</b>–<b>13</b>), one sesquiterpene (<b>14</b>) and three sterols (<b>15</b>–<b>17</b>). The isolated compounds were screened for anticancer and anti-pathogenic bacterial and fungal activities. Based on this work, <i>Xylaria</i> cf. <i>cubensis</i> SWUF08-86 has proven to be a diverse secondary metabolites producer.</p>