A <i>Helicobacter pylori-</i>associated insulin resistance in asymptomatic sedentary young men does not correlate with inflammatory markers and urine levels of 8-iso-PGF<sub>2</sub>-α or 1,4-dihydroxynonane mercapturic acid

<p>A potential contribution of <i>H. pylori</i> contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 <i>H. pylori</i> negative and 12 positive) and measured whole blood glucose, glycated haemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, TNF-alpha and comet assay. As markers of OS, we used urine levels of iso-PGF<sub>2</sub>-α and 1,4-dihydroxynonane mercapturic acid (DHN-MA). Twofold elevation of fasting insulin level and HOMA index in <i>H. pylori</i>–positive subjects (<i>p</i> < .05) was shown. Inflammatory parameters and monocyte DNA damage, urine levels of DHN-MA and iso-PGF2-α did not show significant differences between the groups. The early stage of <i>H. pylori</i>-triggered metabolic derangements in sedentary subjects include development of insulin resistance in <i>H. pylori</i>-positive subjects; however, there is no evidence of systemic inflammatory and OS-related changes.</p>