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A Phosphorescent Rhenium(I) Tricarbonyl Polypyridine Complex Appended with a Fructose Pendant That Exhibits Photocytotoxicity and Enhanced Uptake by Breast Cancer Cells
Version 2 2018-07-11, 20:13
Version 1 2016-02-18, 20:32
journal contribution
posted on 2013-09-23, 00:00 authored by Kenneth Yin Zhang, Karson Ka-Shun Tso, Man-Wai Louie, Hua-Wei Liu, Kenneth Kam-Wing LoWe demonstrated that the cytotoxicity
of a phosphorescent rhenium(I)
polypyridine complex with a fructose pendant was enhanced upon irradiation
and the cellular uptake of the complex was mediated by fructose transporters
and inhibited by unmodified fructose but was independent of glucose-specific
transporters. This complex has been used to image breast cancer cells,
where fructose transporters are overexpressed.
