Fig 8.tif (1017.72 kB)
A Model for lariat RNA inhibits miRNA biogenesis in plants.
figure
posted on 2016-11-21, 18:00 authored by Ziwei Li, Shengpeng Wang, Jinping Cheng, Chuanbin Su, Songxiao Zhong, Qi Liu, Yuda Fang, Yao Yu, Hong Lv, Yun Zheng, Binglian ZhengPri-miRNAs are specifically recruited to the DCL1/HYL1 complex (blue indicated) for processing. In wild type plants, most lariat RNAs (indicated in purple) are quickly debranched by DBR1, only a small portion of lariat RNAs (indicated in red) naturally escapes debranching, also associates with the DCL1/HYL1 complex. In contrast, in dbr1-2, over-accumulated lariat RNAs might be recognized by the DCL1/HYL1 complex, and thus attenuate the association between the DCL1/HYL1 complex and pri-miRNAs, producing less miRNA.
