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A G-Quadruplex Ligand with 10000-Fold Selectivity over Duplex DNA

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posted on 2007-02-14, 00:00 authored by Isabelle M. Dixon, Frédéric Lopez, Agueda M. Tejera, Jean-Pierre Estève, Maria A. Blasco, Geneviève Pratviel, Bernard Meunier
A cationic manganese porphyrin binds strongly and selectively to G-quadruplex DNA. This compound is the most selective G4-ligand reported to date.

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    Journal of the American Chemical Society

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    Duplex DNAA cationic manganese porphyrinLigandcompoundSelectivity

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