pone.0200344.g004.tif (8.43 MB)
APP immunoreactivity is lost in Purkinje neurons upon their neurodegeneration in 10-weeks old NPC1 vs. wt mouse brains.
figure
posted on 2018-07-06, 17:55 authored by Mirsada Causevic, Kristina Dominko, Martina Malnar, Lea Vidatic, Stjepko Cermak, Martina Pigoni, Peer-Hendrik Kuhn, Alessio Colombo, Daniel Havas, Stefanie Flunkert, Jessica McDonald, Jenny M. Gunnersen, Birgit Hutter-Paier, Sabina Tahirovic, Manfred Windisch, Dimitri Krainc, Stefan F. Lichtenthaler, Silva HecimovicAPP (green) is expressed in neurons of the cornu ammonis (CA) regions and dentate gyrus (DG) of the hippocampus, as well as in cortical neurons and Purkinje cells in the cerebellum in 10-weeks old wt mice. Due to profound neurodegeneration, 10-weeks old NPC1 mice show a substantial loss of APP intensity in Purkinje neurons. DAPI (blue) was used to counterstain all nuclei.
History
Usage metrics
Categories
Keywords
Sez 6BACE 1 substrates seizure protein 6Sez 6LAPPlysosomal storage disorder Niemann-Pick type CNPC disease pathogenesisNPC 1- vsβ- amyloid precursor proteinNPC 1 miceendolysosomal pathwayNiemann-Pick type C disease mouse brains4- weeksNPC diseaseBACE 1terminal disease stagePurkinje cell neurodegenerationNPC 1-null cellsNPC 1 vsBACE 1-positive punctaADBACE 1-cleavage10- weeks
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC