APP immunoreactivity is lost in Purkinje neurons upon their neurodegeneration in 10-weeks old NPC1 vs. wt mouse brains.

APP (green) is expressed in neurons of the cornu ammonis (CA) regions and dentate gyrus (DG) of the hippocampus, as well as in cortical neurons and Purkinje cells in the cerebellum in 10-weeks old wt mice. Due to profound neurodegeneration, 10-weeks old NPC1 mice show a substantial loss of APP intensity in Purkinje neurons. DAPI (blue) was used to counterstain all nuclei.