np500906k_si_001.pdf (1.06 MB)
3‑Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus
journal contribution
posted on 2015-04-24, 00:00 authored by Luis Figueroa, Carlos Jiménez, Jaime Rodríguez, Carlos Areche, Renato Chávez, Marlene Henríquez, Mercedes de la
Cruz, Caridad Díaz, Yuri Segade, Inmaculada VacaFour new nitroasterric acid derivatives,
pseudogymnoascins A–C (1–3) and 3-nitroasterric acid (4), along with the two known
compounds questin and pyriculamide, were obtained from the cultures
of a Pseudogymnoascus sp. fungus isolated from an
Antarctic marine sponge belonging to the genus Hymeniacidon. The structures of the new compounds were determined by extensive
NMR and MS analyses. These compounds are the first nitro derivatives
of the known fungal metabolite asterric acid. Several asterric acid
derivatives isolated from other fungal strains have shown antibacterial
and antifungal activities. However, the new compounds described in
this work were inactive against a panel of bacteria and fungi (MIC
> 64 μg/mL).