07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the
Marine-Derived Xylariaceous Fungus LL-07H239

McDonald, Leonard A.; Barbieri, Laurel R.; Bernan, Valerie S.; Janso, Jeffrey; Lassota, Peter; Carter, Guy T.

doi:10.1021/np049924g.s001

np049924g_si_001.pdf (144.65 kB)

07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the Marine-Derived Xylariaceous Fungus LL-07H239

journal contribution

posted on 2004-09-24, 00:00 authored by Leonard A. McDonald, Laurel R. Barbieri, Valerie S. Bernan, Jeffrey Janso, Peter Lassota, Guy T. Carter

07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC₅₀ = 0.9 μg/mL).