Ar1168-1.jpg (55.71 kB)
The RNA interference pathway
figure
posted on 2011-12-30, 14:17 authored by Sascha Rutz, Alexander ScheffoldCopyright information:
Taken from "Towards application of RNA interference – new toys, old problems"
Arthritis Research & Therapy 2004;6(2):78-85.
Published online 10 Mar 2004
PMCID:PMC400443.
Copyright © 2004 BioMed Central Ltd
Long double-stranded RNA (dsRNA) or small hairpin RNA (shRNA) is processed by Dicer to form a small interfering RNA (siRNA), which associates with RNA-induced silencing protein complex (RISC) and mediates target sequence specificity for subsequent mRNA cleavage. (See text for further details.)