miR-122 over-expression inhibited in-vitro cell proliferation and in-vivo tumor growth in a highly transformed HCC SNU-182 xenograft mouse model.

Cell proliferation was measured in (A) SNU-182 and (C) Huh-7 parental cells and cells stably over-expressing miR-122-GFP or GFP alone. (B) Cell proliferation was measured in SNU-182 cells over-expressing miR-122-GFP or GFP with or without the reconstitution of AKT3 expression. (D) Nude mice were implanted with SNU-182 parental lines as well as cells over-expressing miR-122-GFP or GFP vector alone, and tumor growth was monitored and plotted as tumor volume (mm³) over time. Statistical significance between the indicated groups are depicted as ** P<0.01, and *** P<0.005.