Figure_8.tif (867.17 kB)
mENT1 inhibition by NBMPR chemoprotects APL cells from Ara-C and gemcitabine-induced cell death.
figure
posted on 2013-02-20, 04:53 authored by Patricia Macanas-Pirard, Andrea Leisewitz, Richard Broekhuizen, Kelly Cautivo, Francisco M. Barriga, Francisco Leisewitz, Victoria Gidi, Erick Riquelme, Viviana P. Montecinos, Pilar Swett, Pelayo Besa, Pablo Ramirez, Mauricio Ocqueteau, Alexis M. Kalergis, Matthew Holt, Michael Rettig, John F. DiPersio, Bruno NerviAPL cells were cultured alone or with M2-BM SN with pre-treatment with NBMPR (1 µM) for 2 hours before normal treatment with Ara-C (250 ng/ml) (A) or gemcitabine (75 ng/ml) (B) for 24 hours. Cell viability was measured by the MTT assay. Data are the mean ±SD of at least three independent experiments. ***p<0.001 (APL versus APL + NBMPR).
