Tumor growth, long term responders and survival of nude mice with Ramos xenografts after treatment with 530 MBq/kg ¹⁷⁷Lu-HH1, 530 MBq/kg ¹⁷⁷Lu-rituximab, 530 MBq/kg ¹⁷⁷Lu-IgG₁ non-specific isotype control, 15 μg/kg HH1 and 0.9% NaCl.

(A) Individual tumor growth (n = Number of tumors in remission at the end of study/total number of initial tumors); (B) Percentage of long term responders (mice euthanized due to radiation toxicity symptoms or for hematology measurements before one of their tumors reached a volume of 2000 mm³ were not considered in the analysis); (C) Kaplan-Meier survival curve. End point: tumor volume ≥ 4 times initial tumor volume. Crosses represent censored animals that were euthanized before reaching 4 times the initial tumor volume. N = 9–10. Multiple comparisons were performed using Holm Sidak method. Significance level: p < 0.05.