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Transcription factor binding site analysis.
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posted on 2015-06-18, 04:43 authored by Jörg Bartel, Jan Krumsiek, Katharina Schramm, Jerzy Adamski, Christian Gieger, Christian Herder, Maren Carstensen, Annette Peters, Wolfgang Rathmann, Michael Roden, Konstantin Strauch, Karsten Suhre, Gabi Kastenmüller, Holger Prokisch, Fabian J. TheisA: Heatmap of shared significantly overrepresented TFBS between metabolic subpathways. Upper right triangle matrix was left out. Darker colors indicate a higher number of shared TF binding sites. B+C: Identified network motifs of TFs and their respective target genes associated to the same metabolite. Green arrows indicate regulation. Black lines indicate positive correlation; red dotted lines indicate negative correlation.
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association712 individualsBMTIpathway levelpopulation studiesBidirectional causality analysisacid metabolismSimultaneous analysisGerman KORA F 4 cohortgain novel insightstranscription factor binding site enrichment analysis114 metabolites522 transcriptsfasting serum metabolomicsmechanismMendelian randomizationblood transcriptomics data
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