Figure_2.tif (1.39 MB)
The DFG Motif Conformation.
figure
posted on 2014-09-08, 03:17 authored by Yankun Duan, Lin Chen, Yongheng Chen, Xue-gong Fan(A) active Lck DFG-in conformation (pdb: 3LCK); (B) active c-Src T338I DFG-in conformation (pdb: 3DQW); (C) active c-Src DFG-in conformation in Src/Ruxolitinib complex (this work); (D) inactive c-Src in the Src/CDK conformation, DFG-intermediate (pdb: 2SRC); (E) inactive c-Src DFG-out conformation in Src/Imatinib complex (pdb: 2OIQ).
