Figure_12.tif (9.15 MB)
T-cell infiltration as determined by CD3 immunohistochemistry.
figure
posted on 2013-03-01, 16:27 authored by Bart F. J. Heijnen, Jelly Nelissen, Helma van Essen, Gregorio E. Fazzi, Jan W. Cohen Tervaert, Carine J. Peutz-Kootstra, John J. Mullins, Casper G. Schalkwijk, Ben J. A. Janssen, Harry AJ. Struijker-BoudierCD3 staining of kidneys revealed a time-dependent increase of T-cells after stopping the 4 weeks of RAS-stimulation in I3C-treated animals. Losartan completely prevented this rise in T-cells. These results are in line with the data on renal gene expression. The n for each group is presented in the bars of the GSI. GSI, glomerulosclerosis index; I3C, Indole-3-Carbinol; TIS, tubulointerstitial score.
