Figure_5.tif (629.97 kB)

TRD at R2d2 requires the combined action of meiotic drive and embryonic lethality.

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posted on 2015-02-13, 02:45 authored by John P. Didion, Andrew P. Morgan, Amelia M.-F. Clayshulte, Rachel C. Mcmullan, Liran Yadgary, Petko M. Petkov, Timothy A. Bell, Daniel M. Gatti, James J. Crowley, Kunjie Hua, David L. Aylor, Ling Bai, Mark Calaway, Elissa J. Chesler, John E. French, Thomas R. Geiger, Terry J. Gooch, Theodore Garland Jr., Alison H. Harrill, Kent Hunter, Leonard McMillan, Matt Holt, Darla R. Miller, Deborah A. O'Brien, Kenneth Paigen, Wenqi Pan, Lucy B. Rowe, Ginger D. Shaw, Petr SimecekPetr Simecek, Patrick F. Sullivan, Karen L Svenson, George M. Weinstock, David W. Threadgill, Daniel Pomp, Gary A. Churchill, Fernando Pardo-Manuel de Villena

Relationship between maternal TR and average litter size (top panels) and average number of offspring inheriting alternative alleles at R2d2 (bottom panels) for A) DO G13 dams, B) DO G16 dams, C) G3 dams in the D0-G13–44 pedigree and D) (NZO/HILtJxWSB/EiJ)F1 dams. Top panels: gray circles are dams without TRD (A, B, D) or having the low-copy allele (C); blue circles are dams with TRD (A, B, D) or having the high-copy allele (C). For each point, bars show standard error for TR (horizontal) and average litter size (vertical). Dotted lines show mean litter sizes for each type of female. Red line shows a linear fit to TR and average litter size. Bottom panels: left and right pairs of boxplots show average number of offspring per litter in females without and with TRD (A, B, D) or having the low- and high-copy allele (C) that inherit a WSB/EiJ (purple) or non-WSB/EiJ (gray) allele. Females with a mutant R2d2^WSB allele are excluded. Note that there are significantly more WSB/EiJ offspring of dams with TRD in F1 hybrid dams than in DO without TRD.