Figure_4.tif (3.68 MB)
Suppression of ERK1/2 activation in human HCC cell attenuates EMT-like process following by migration and invasion induced by hypoxia.
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posted on 2013-10-29, 03:10 authored by Shao-guang Huang, Le-le Zhang, Qin Niu, Gui-ming Xiang, Lin-lin Liu, Dong-neng Jiang, Fei Liu, Yi Li, Xiaoyun Pu(A) GLIPR-2, p-ERK1/2 and EMT markers expression in HepG2 cells after hypoxia 48 h or treated with 5,20 µM PD 98059. GLIPR-2 expression was elevated after hypoxia 48 h. (B) Hypoxia promotes HepG2 cells migration, invasion via ERK1/2 activation. Data are presented as mean ± SD. *P<0.01 compared with the normoxia group (black bar), ANOVA. #P<0.01 compared with the hypoxia group (grey bar), ANOVA.
