Figure_1.tif (10.38 MB)
Study design and representative micrograph showing DOX-related vacuolation in the myocardium.
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posted on 2012-07-31, 02:30 authored by Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R. Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K. Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S. Paules, François Pognan, Frank Staedtler, Martin P. Vidgeon-Hart, Olivier Grenet, Philippe Couttet(A) Six adult male rats were injected with the indicated doses of vehicle, doxorubicin (DOX), dexrazoxane (DZR), etoposide (EPS) or a combination of DOX and DZR for 2, 4 or 6 weeks. Cardiac tissue was excised and deep frozen for gene expression and microRNA profiling experiments. A representative micrograph of a toluidine blue stained myocardial section of a control (B) and of a DOX treated animal (C). Black arrows indicate sarcoplasmic micro- and macro- vacuolation of cardiomyocytes.
