Representative microphotographs of different sites of the brain and spinal cord of l2hgdh^-/- compared to l2hgdh^+/+ mice.

A-D, transverse sections through the corpus callosum (cc); E-H, transverse sections through the hippocampus (dg, dentate gyrus); I-L, sections through the cerebellum and cerebellar nuclei (cn); M-P, transverse sections through the spinal cord (ah, anterior horn). Left panels (A, B, E, F, I, J, M, N) are representative of l2hgdh^+/+ mice and right panels (C, D, G, H, K, L, O, P) of l2hgdh^-/- mice. On each side, the right panel is a higher magnification of the left panel, where arrows indicate lesions seen in brains of l2hgdh^-/- mice. Scale bars correspond to 300 μm or 50 μm as indicated.