Figure_2.tif (382.33 kB)
Recruitment of KDM2A and anti-dimethyl-H3K36 (H3K36me2) at Atp2a2 and Myh7 gene promoter regions in TAC hearts.
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posted on 2014-09-02, 03:49 authored by Tiziana Angrisano, Gabriele Giacomo Schiattarella, Simona Keller, Gianluigi Pironti, Ermanno Florio, Fabio Magliulo, Roberta Bottino, Raffaela Pero, Francesca Lembo, Enrico Vittorio Avvedimento, Giovanni Esposito, Bruno Trimarco, Lorenzo Chiariotti, Cinzia PerrinoChIP experiments were performed using antibodies indicated in each panel: A KDM2A; B–C anti-dimethyl-H3K36 (H3K36me2). Each experiment was repeated at least three times, and the quantitative PCR analyses were performed in triplicate. The data are presented as percentages (%) of input DNA (mean ± SD; *p<0.05 vs. SHAM; **p<0.01 vs. SHAM; n = 4–6 hearts/group).
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gene expression programgene expression reprogrammingDNA methyltransferases DNMT 1Myh 7 Gene Promoterstacpromoter regions2asercahfAtp 2amhcadult murine heartH 3KkdmMyh 7 promotershistone H 3 modificationsH 3K H 3 trimethylationH 3 dimethylationpressure overloadDNA methylation machinery componentshistone chromatin modificationsAtp 2a promoter
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