Prefrontal cortical distribution of significant effect of the COMT genotype on [oxy-Hb] changes in patients with schizophrenia.

The channels with a significant genotype difference (P≤0.05) between the Met carriers and the Val/Val individuals among patients with schizophrenia are indicated by colored areas. To illustrate the gradation in P value over the prefrontal cortical surface area, channels with FDR-corrected P<0.0019 are colored in red, 0.0019≤P<0.01 in orange, and P≤0.05 in yellow. These areas approximately correspond to the bilateral frontopolar (BA 10), dorsolateral (BA 9 and 46), and ventrolateral (BA 44 and 45) prefrontal regions.